Hypertension Highlights Sympathetic Nervous System and Blood Pressure in Humans Individualized Patterns of Regulation and Their Implications

The autonomic nervous system and its sympathetic arm play important roles in the regulation of blood pressure.1–3 Their role in the short-term regulation of blood pressure, especially in responses to transient changes in arterial pressure, via baroreflex mechanisms is well known.4 However, the role of the sympathetic branch in longer-term (days, months, and years) blood pressure regulation has been a focus of debate since at least the 1970s.1,4 Our goal in this Hypertension Highlights is to summarize and integrate our ideas on the role of the sympathetic nervous system in long-term blood pressure regulation in humans.1–3,5–9 We will focus primarily on information from studies conducted in humans and use data from animal studies to emphasize key points. In this context, we want to address 4 key questions. The first 3 focus on our recent work. The final issue is an emerging one and more speculative. First, what is the role of the sympathetic nervous system in long-term blood pressure regulation in young (18to 40-year–old) normotensive men? Second, does the role of the sympathetic nervous system in long-term blood pressure regulation change as a function of age in men? Third, does sex influence the role of the sympathetic nervous system in long-term blood pressure regulation, and are sex differences modified by aging? Fourth, are we entering an era of sympathetically driven hypertension? Before we address these questions, we share a few thoughts about how to assess the overall activity of sympathetic nerves in humans.